Opportunity Information: Apply for PA 19 089
The Mentored Quantitative Research Development Award (Parent K25 - Independent Basic Experimental Studies with Humans Required), PA-19-089, is an NIH career development grant intended to pull experienced quantitative scientists and engineers into NIH-relevant biomedical and behavioral research. The core idea is to support people who have already demonstrated productivity in fields like mathematics, statistics, economics, computer science, informatics, imaging science, physics, chemistry, or engineering, but whose past work has not primarily focused on health and disease. Through mentored training, structured career development, and dedicated protected time, the K25 is meant to help these investigators integrate their quantitative expertise into research questions that matter to NIH missions and to position them for long-term independence in health-related research.
This specific FOA is tailored to applicants who will lead basic experimental studies involving human participants. NIH classifies these as prospective basic science studies involving human participants, meaning the work both fits the NIH definition of a clinical trial and is also considered basic research. In practical terms, the targeted projects are those where human participants are prospectively assigned to conditions and the investigator experimentally manipulates one or more independent variables, then measures biomedical or behavioral outcomes in humans. The goal of these studies is fundamental understanding of phenomena rather than developing or testing a product, process, or applied intervention. If the proposed human study is oriented toward specific applications, such as optimizing a process or evaluating a product-oriented outcome, NIH directs applicants instead to the companion announcement PA-18-395, which is designed for clinical trial work with an applied or translational emphasis.
The opportunity is offered by the National Institutes of Health and uses a grant funding instrument within a broad activity category that includes education, health, and related social service domains. Multiple CFDA program numbers are associated with this FOA (93.113, 93.121, 93.173, 93.273, 93.279, 93.865, 93.866), reflecting that different NIH Institutes and Centers may support awards under this umbrella depending on the scientific fit.
Eligibility is broad across U.S.-based organizational types that commonly host NIH-funded research and career development programs. Eligible applicants include public and private institutions of higher education, nonprofits with or without 501(c)(3) status (as long as they are not institutions of higher education when categorized that way), for-profit organizations other than small businesses, small businesses, and a range of government entities (state, county, city or township, special district governments, independent school districts, and eligible federal agencies). It also includes Native American tribal governments (federally recognized) and other Native American tribal organizations. NIH also highlights several institution types that may apply, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations and U.S. territories or possessions.
At the same time, the FOA draws clear lines around non-U.S. applicants. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply as the applicant organization, and non-domestic components of U.S. organizations are not eligible. However, foreign components, as NIH defines them in the NIH Grants Policy Statement, are allowed. In other words, the award must be led by an eligible U.S.-based applicant organization, but certain project elements may include foreign components if they meet NIH policy requirements and are justified scientifically.
The original closing date listed for this opportunity was May 7, 2020, and the FOA record indicates it was created on November 28, 2018. The provided listing does not specify an award ceiling or expected number of awards in the source fields shown, which typically means applicants would need to consult the full NIH FOA text and the relevant Institute/Center guidance for budgeting expectations, award duration details, and institute-specific paylines or caps. Overall, PA-19-089 is best understood as a mentored, protected-time career development pathway for quantitatively trained researchers who want to pivot into NIH-relevant work, specifically through leading rigorously designed, experimentally manipulated basic studies in humans that qualify as clinical trials but are aimed at fundamental scientific understanding rather than immediate application.Apply for PA 19 089
- The National Institutes of Health in the education, environment, health, income security and social services sector is offering a public funding opportunity titled "Mentored Quantitative Research Development Award (Parent K25 - Independent Basic Experimental Studies with Humans Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.173, 93.273, 93.279, 93.865, 93.866.
- This funding opportunity was created on 2018-11-28.
- Applicants must submit their applications by 2020-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the Mentored Quantitative Research Development Award (Parent K25) described here?
It is an NIH career development grant (K25) designed to bring experienced quantitative scientists and engineers into NIH-relevant biomedical and behavioral research. The award supports mentored training, structured career development, and protected time so recipients can integrate their quantitative expertise into health-related research and move toward long-term independence.
Which FOA is this, and what is its identifier?
This opportunity is the Mentored Quantitative Research Development Award (Parent K25 - Independent Basic Experimental Studies with Humans Required), FOA number PA-19-089.
Who is this award intended to support (in terms of background and prior work)?
It targets investigators who have already demonstrated productivity in quantitative fields such as mathematics, statistics, economics, computer science, informatics, imaging science, physics, chemistry, or engineering, but whose prior work has not primarily focused on health and disease. The intent is to support a pivot into NIH-mission-relevant biomedical and behavioral research.
What is the main purpose of the K25 in this announcement?
The purpose is to support a mentored pathway that helps quantitatively trained researchers apply their skills to NIH-relevant research questions, through structured career development activities and dedicated protected time, with the goal of positioning them for independent, long-term careers in health-related research.
Does this FOA require research involving human participants?
Yes. This specific FOA is tailored to applicants who will lead basic experimental studies involving human participants, under NIH’s category of “Independent Basic Experimental Studies with Humans Required.”
How does NIH describe the type of human research expected under this FOA?
NIH describes the targeted work as prospective basic science studies involving human participants that both meet the NIH definition of a clinical trial and are also considered basic research. In these studies, human participants are prospectively assigned to conditions, the investigator experimentally manipulates one or more independent variables, and biomedical or behavioral outcomes are measured in humans.
What is meant by “basic experimental studies with humans” in practical terms?
In practical terms, it refers to studies where the investigator prospectively assigns human participants to different conditions, actively manipulates one or more independent variables, and measures outcomes in humans. The emphasis is on fundamental understanding of phenomena rather than developing or testing a product, process, or applied intervention.
If my human study is applied or translational, is this the right FOA?
Not necessarily. NIH indicates that if the proposed human study is oriented toward specific applications (for example, optimizing a process or evaluating a product-oriented outcome), applicants should look to the companion announcement PA-18-395, which is intended for clinical trial work with an applied or translational emphasis.
What is the key distinction between PA-19-089 and the companion announcement PA-18-395?
PA-19-089 is focused on basic experimental studies with humans that qualify as clinical trials but are aimed at fundamental scientific understanding. PA-18-395 is intended for clinical trial work that is more applied or translational in emphasis.
Which agency offers this funding opportunity?
The opportunity is offered by the National Institutes of Health (NIH).
What general activity area does this opportunity fall under?
It uses a grant funding instrument within a broad activity category that includes education, health, and related social service domains.
Why are multiple CFDA program numbers listed for this FOA?
Multiple CFDA program numbers are associated with this FOA (93.113, 93.121, 93.173, 93.273, 93.279, 93.865, 93.866) because different NIH Institutes and Centers may support awards under this announcement depending on the scientific fit.
What types of U.S. organizations are eligible to apply?
Eligibility is broad across U.S.-based organizations that commonly host NIH-funded research and career development programs. Eligible applicants include public and private institutions of higher education; nonprofits with or without 501(c)(3) status (when not categorized as institutions of higher education); for-profit organizations other than small businesses; small businesses; and government entities such as state, county, city or township, special district governments, independent school districts, and eligible federal agencies.
Are tribal governments or tribal organizations eligible?
Yes. Eligibility includes Native American tribal governments (federally recognized) and other Native American tribal organizations.
Does NIH specifically encourage applications from certain institution types?
NIH highlights that several institution types may apply, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It also notes faith-based or community-based organizations and U.S. territories or possessions.
Are non-U.S. (foreign) institutions eligible to apply as the applicant organization?
No. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply as the applicant organization for this FOA.
Are non-domestic components of U.S. organizations allowed?
No. The FOA states that non-domestic components of U.S. organizations are not eligible.
Are any foreign activities allowed at all under this FOA?
Yes. Although the applicant organization must be an eligible U.S.-based entity, foreign components (as NIH defines them in the NIH Grants Policy Statement) are allowed if they meet NIH policy requirements and are scientifically justified.
What does it mean that foreign components are allowed but foreign institutions cannot apply?
It means the award must be led by an eligible U.S. applicant organization, but certain parts of the project may involve a foreign component if it fits NIH’s definition and is allowable under NIH policy.
When was this FOA created, and what closing date is listed?
The FOA record indicates it was created on November 28, 2018, and the original closing date listed was May 7, 2020.
Does the provided listing include an award ceiling or the expected number of awards?
No. The provided listing does not specify an award ceiling or the expected number of awards in the source fields shown.
Where should applicants look for budgeting expectations and award details not shown here?
Because the listing does not provide a budget ceiling, expected number of awards, or other institute-specific limits, applicants would typically need to consult the full NIH FOA text and relevant Institute/Center guidance for budgeting expectations, award duration details, and any institute-specific caps.
What is the overall “best understood” summary of PA-19-089 based on the description?
It is a mentored, protected-time career development pathway for quantitatively trained researchers to pivot into NIH-relevant biomedical and behavioral research, specifically by leading rigorously designed basic experimental studies in humans that qualify as clinical trials but are intended to generate fundamental scientific understanding rather than immediate application.
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| Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Basic Experimental Studies with Humans Required) Apply for PA 19 087 Funding Number: PA 19 087 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Clinical Scientist Research Career Development Award (Parent K08 - Independent Basic Experimental Studies with Humans Required) Apply for PA 19 086 Funding Number: PA 19 086 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: NeuroImaging Tools and Resources Collaboratory (R24 Clinical Trial Not Allowed) Apply for RFA EB 18 004 Funding Number: RFA EB 18 004 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $600,000 |
| HEAL Initiative: HEALthy Brain and Child Development Study (HEALthy BCD) (Collaborative R34- Clinical Trial Not Allowed) Apply for RFA DA 19 029 Funding Number: RFA DA 19 029 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $225,000 |
| Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed) Apply for PAR 19 134 Funding Number: PAR 19 134 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $300,000 |
| HEAL Initiative: HEALthy Brain and Child Development Study (HEALthy BCD) ( R34- Clinical Trial Not Allowed) Apply for RFA DA 19 036 Funding Number: RFA DA 19 036 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $225,000 |
| Limited Competition for a Connectome Coordination Facility (R24 Clinical Trial Not Allowed) Apply for RFA MH 20 210 Funding Number: RFA MH 20 210 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $900,000 |
| Transformative Research Award for the INCLUDE (Investigation of Co-occurring Conditions across the Lifespan to Understand Down syndrome) Project (R01 Clinical Trial Not Allowed) Apply for RFA OD 19 016 Funding Number: RFA OD 19 016 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Clinical Trials Development for Co-Occurring Conditions in Individuals with Down syndrome: Phased Awards for INCLUDE (R61/R33 Clinical Trials Required) Apply for RFA OD 19 018 Funding Number: RFA OD 19 018 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Clinical Trial Readiness (R21 Clinical Trial Not Allowed) Apply for RFA OD 19 015 Funding Number: RFA OD 19 015 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $200,000 |
| PHS 2019-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required Apply for PA 19 273 Funding Number: PA 19 273 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Dissemination and Implementation Research in Health (R03 Clinical Trial Not Allowed) Apply for PAR 19 276 Funding Number: PAR 19 276 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $50,000 |
| Dissemination and Implementation Research in Health (R01 Clinical Trial Optional) Apply for PAR 19 274 Funding Number: PAR 19 274 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Marmoset Coordination Center (U24 Clinical Trials Not Allowed) Apply for RFA MH 20 150 Funding Number: RFA MH 20 150 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Marmoset Colonies for Neuroscience Research (U24 Clinical Trials Not Allowed) Apply for RFA MH 20 145 Funding Number: RFA MH 20 145 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Blueprint for Neuroscience Research Education Program on Translational Devices (R25 Clinical Trial Not Allowed) Apply for RFA NS 20 003 Funding Number: RFA NS 20 003 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $250,000 |
| NIH Blueprint Program for Enhancing Neuroscience Diversity through Undergraduate Research Education Experiences (BP-ENDURE) (R25 Clinical Trial Not Allowed) Apply for RFA NS 20 015 Funding Number: RFA NS 20 015 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Clinical Trial Readiness (R21 Clinical Trial Not Allowed) Apply for RFA OD 20 004 Funding Number: RFA OD 20 004 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $200,000 |
| Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32) Apply for PA 20 142 Funding Number: PA 20 142 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required) Apply for PA 20 184 Funding Number: PA 20 184 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
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