Opportunity Information: Apply for RFA MD 24 005
Elucidating Mechanisms Associated with HIV Related Co-Morbidities in Populations Experiencing Health Disparities (R01 - Clinical Trials Not Allowed) is a National Institutes of Health (NIH) funding opportunity (RFA-MD-24-005) designed to support research that digs into the biological, behavioral, social, and structural mechanisms driving unequal health outcomes among people living with HIV, particularly as they age and accumulate multiple co-morbidities. The core aim is not simply to document that disparities exist, but to clarify why they occur by identifying underlying pathways that connect HIV, aging, and co-occurring conditions to downstream outcomes like overall health status, disease progression, functioning, and quality of life in populations that experience health disparities.
A central emphasis of this opportunity is the interaction between HIV and aging in the context of multimorbidity. Applicants are expected to focus on how having multiple co-morbidities at once (for example, cardiometabolic disease, liver or kidney disease, neurocognitive changes, mental health conditions, or other chronic disorders common in aging) influences health trajectories for people with HIV, and how these patterns differ in groups facing persistent inequities. The funding call highlights mechanism-focused research, meaning projects should be structured to explain processes and pathways (such as inflammation and immune activation, treatment-related effects, stress biology, care access dynamics, or other plausible causal chains) that contribute to disparity-linked differences in outcomes, rather than primarily testing an intervention in a clinical trial setting.
The award mechanism is an NIH R01 research project grant, and clinical trials are not allowed under this announcement. In practical terms, that generally steers applicants toward observational studies, analyses of existing cohorts or datasets, mechanistic laboratory or translational studies tied to human populations, or other designs that can credibly illuminate causal or explanatory mechanisms without conducting a clinical trial. The opportunity sits within NIH activity categories related to health (CFDA numbers 93.307 and 93.847), and it is listed as a discretionary grant program.
Eligibility is broad across many U.S.-based organizations. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; public housing authorities/Indian housing authorities; and federally recognized Native American tribal governments, as well as Native American tribal organizations that are not federally recognized. The announcement also explicitly calls out additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. Despite that wide net, non-U.S. entities are not eligible: non-domestic (non-U.S.) organizations cannot apply, non-domestic components of U.S. organizations are not eligible, and foreign components (as defined by the NIH Grants Policy Statement) are not allowed.
Key administrative details included in the source information are that the program is run by NIH, the original closing date is January 7, 2026, and the listed award ceiling is $500,000. The opportunity record shows a creation date of March 1, 2024. The number of expected awards is not specified in the provided source data.Apply for RFA MD 24 005
- The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Elucidating Mechanisms Associated with HIV Related Co-Morbidities in Populations Experiencing Health Disparities (R01 - Clinical Trials Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.307, 93.847.
- This funding opportunity was created on 2024-03-01.
- Applicants must submit their applications by 2026-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The funding opportunity is titled "Elucidating Mechanisms Associated with HIV Related Co-Morbidities in Populations Experiencing Health Disparities (R01 - Clinical Trials Not Allowed)." It is an NIH opportunity with the reference number RFA-MD-24-005.
Which agency is offering this grant?
This opportunity is offered by the National Institutes of Health (NIH).
What is the primary purpose of this funding opportunity?
The purpose is to support research that explains the biological, behavioral, social, and structural mechanisms that drive unequal health outcomes among people living with HIV, especially as they age and experience multiple co-morbidities. The emphasis is on clarifying why disparities occur by identifying underlying pathways linking HIV, aging, and co-occurring conditions to outcomes such as overall health status, disease progression, functioning, and quality of life.
Is the goal to document disparities or to explain them?
The core aim is not simply to document that disparities exist, but to clarify why they occur by identifying mechanisms and pathways that contribute to unequal outcomes.
What research focus does NIH emphasize in this announcement?
The announcement emphasizes mechanism-focused research, particularly research that examines the interaction between HIV and aging in the context of multimorbidity (having multiple co-morbidities at once) in populations experiencing health disparities.
What does "multimorbidity" mean in the context of this opportunity?
In this context, multimorbidity refers to the presence of multiple co-morbidities at the same time for a person living with HIV. The opportunity highlights that applicants should consider how multiple co-occurring conditions shape health trajectories as people age, and how these trajectories differ across groups experiencing persistent inequities.
What kinds of co-morbidities are mentioned as examples?
Examples listed include cardiometabolic disease, liver or kidney disease, neurocognitive changes, mental health conditions, and other chronic disorders common in aging.
What types of mechanisms or pathways are applicants expected to study?
The opportunity mentions mechanisms such as inflammation and immune activation, treatment-related effects, stress biology, and care access dynamics, as well as other plausible causal chains that link HIV, aging, and co-morbidities to downstream outcomes.
What grant mechanism will be used?
The award mechanism is an NIH R01 research project grant.
Are clinical trials allowed under this announcement?
No. Clinical trials are not allowed under this funding opportunity.
What kinds of study designs does this opportunity generally steer applicants toward?
Because clinical trials are not allowed, the description indicates a practical emphasis on approaches such as observational studies, analyses of existing cohorts or datasets, and mechanistic laboratory or translational studies tied to human populations, or other designs that can illuminate causal or explanatory mechanisms without conducting a clinical trial.
Does this opportunity support intervention testing in a clinical trial setting?
The opportunity emphasizes explaining processes and pathways rather than primarily testing an intervention in a clinical trial setting, and clinical trials are explicitly not allowed.
Who is eligible to apply?
Eligibility is broad across many U.S.-based organizations. Eligible applicants include various government entities (state, county, city or township, and special district governments), independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status, other than institutions of higher education), for-profit organizations (other than small businesses), small businesses, public housing authorities/Indian housing authorities, and Native American tribal governments and tribal organizations (including those not federally recognized).
Are minority-serving institutions and community-based organizations eligible?
Yes. The opportunity explicitly notes additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
Can non-U.S. (foreign) organizations apply?
No. Non-domestic (non-U.S.) organizations cannot apply under this announcement.
Can a U.S. organization include non-U.S. components or foreign components in the application?
No. The provided information states that non-domestic components of U.S. organizations are not eligible and that foreign components (as defined by the NIH Grants Policy Statement) are not allowed.
What are the CFDA numbers associated with this opportunity?
The opportunity is associated with CFDA numbers 93.307 and 93.847.
Is this a discretionary grant program?
Yes. The opportunity is listed as a discretionary grant program.
What is the application deadline (closing date)?
The original closing date provided is January 7, 2026.
What is the award ceiling listed for this opportunity?
The listed award ceiling is $500,000.
How many awards does NIH expect to make?
The number of expected awards is not specified in the provided source information.
When was this opportunity record created?
The opportunity record shows a creation date of March 1, 2024.
What outcomes or endpoints does the opportunity highlight as relevant?
The description highlights downstream outcomes such as overall health status, disease progression, functioning, and quality of life, particularly as they relate to the combined effects of HIV, aging, and multiple co-morbidities in populations experiencing health disparities.
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| Pilot Studies of Biological, Behavioral and Social Mechanisms Contributing to HIV Pathogenesis Within the Mission of NIDDK (R21 Clinical Trial Not Allowed) Apply for PAR 24 162 Funding Number: PAR 24 162 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
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| Discovery of Early Type 1 Diabetes Disease Processes in the Human Pancreas [HIRN Consortium on Beta Cell Death and Survival (CBDS)] (U01 Clinical Trial Not Allowed) Apply for RFA DK 23 007 Funding Number: RFA DK 23 007 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $550,000 |
| Adaptation of Diabetes Control Technologies for Older Adults with T1D (R01 Clinical Trial Optional) Apply for RFA DK 24 002 Funding Number: RFA DK 24 002 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| Kidney Technology Development Research Education Program (R25 - Independent Clinical Trial Not Allowed) Apply for RFA DK 25 009 Funding Number: RFA DK 25 009 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $130,000 |
| Cystic Fibrosis Research and Translation Centers (P30 Clinical Trial Optional) Apply for RFA DK 25 010 Funding Number: RFA DK 25 010 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $750,000 |
| Coordinating Center for Type 1 Diabetes TrialNet (U01 Clinical Trial Required) Apply for RFA DK 25 004 Funding Number: RFA DK 25 004 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Type 1 Diabetes TrialNet Clinical Network Hub (U01 Clinical Trial Not Allowed) Apply for RFA DK 25 005 Funding Number: RFA DK 25 005 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Nutrition Obesity Research Centers Research Resource Center (RRC) (P2C- Clinical Trial Optional) Apply for RFA DK 25 011 Funding Number: RFA DK 25 011 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $625,000 |
| Nutrition Obesity Research Centers (P30 Clinical Trial Optional) Apply for RFA DK 25 007 Funding Number: RFA DK 25 007 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Single Source for the Continuation of the Human Pancreas Analysis Program (HPAP) for Type 1 Diabetes (HPAP-T1D) (U01 Clinical Trial Not Allowed) Apply for RFA DK 25 012 Funding Number: RFA DK 25 012 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $5,500,000 |
| Single Source for Chronic Pancreatitis Clinical Research Consortium (CPCRC) Data Coordinating Center (CPCRC-DCC) (U01 Clinical Trial Optional) Apply for RFA DK 25 020 Funding Number: RFA DK 25 020 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $1,000,000 |
| The Chronic Pancreatitis Clinical Research Consortium (CPCRC)- Clinical Centers (CPCRC-CCs) (U01 Clinical Trial Optional) Apply for RFA DK 25 019 Funding Number: RFA DK 25 019 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $400,000 |
| Limited Competition: Small Grant Program for NIDDK K01/K08/K23 Recipients (R03) Apply for PAR 15 343 Funding Number: PAR 15 343 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Impact of the Use of Glucose Monitoring and Control Technologies on Health Outcomes and Quality of Life in Older Adults with Type 1 Diabetes (T1D) (DP3) Apply for RFA DK 15 028 Funding Number: RFA DK 15 028 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Research Using Biosamples and Subjects from Type 1 Diabetes Clinical Studies Complications (DP3) Apply for RFA DK 15 019 Funding Number: RFA DK 15 019 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $1,000,000 |
| Toward ElucidAting MechanismS of HIV Pathogenesis within the Mission of the NIDDK (Pathogenesis TEAMS) (R01 Clinical Trial Optional) Apply for RFA DK 25 024 Funding Number: RFA DK 25 024 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| Central Coordinating Site for the Polycystic Kidney Disease Research Core Centers (U24 Clinical Trial Not Allowed) Apply for RFA DK 25 015 Funding Number: RFA DK 25 015 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Polycystic Kidney Disease Core Centers (U54 Clinical Trial Not Allowed) Apply for RFA DK 25 016 Funding Number: RFA DK 25 016 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Single Source for the Continuation of the Type 1 Diabetes in Acute Pancreatitis Consortium - Data Coordinating Center (T1DAPC-DCC) (U01 Clinical Trial Optional) Apply for RFA DK 25 018 Funding Number: RFA DK 25 018 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $800,000 |
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