Opportunity Information: Apply for RFA CA 17 001
The Canine Immunotherapy Trials and Correlative Studies (U01) funding opportunity (RFA-CA-17-001) is a National Institutes of Health cooperative agreement designed to push forward cancer immunotherapy research by using pet dogs that naturally develop cancer (spontaneous tumors). The main idea is to run real clinical studies in canine patients using immunotherapeutic agents and carefully chosen new combinations of treatments, then pair those trials with detailed laboratory correlative work. The clinical side tests whether a therapy or combination actually helps dogs with cancer, while the laboratory side digs into why it helped, why it did not, and which cellular and molecular mechanisms are driving response versus resistance. In practice, this kind of program is meant to generate translational insights that can improve veterinary oncology and also inform human cancer immunotherapy, since spontaneous cancers in dogs often share important biological and immunological features with human cancers and occur in an immune-competent setting.
The FOA specifically supports trials that involve immunotherapies as well as novel combinations that may include immune modulators, molecularly targeted agents, chemotherapy, and/or radiation. The emphasis is not only on testing a drug, but on understanding the immune and tumor biology around it. That is where the correlative studies come in: applicants are expected to build strong laboratory components that can characterize immune cell behavior, tumor microenvironment changes, molecular signaling, and other biomarkers that may predict which dogs respond or fail to respond. The goal is a more complete picture of anti-tumor immune activity in a real-world, naturally occurring cancer context, rather than relying solely on experimental or artificial tumor models.
A key structural feature of the program is that it is intended to create or expand a network of participating laboratories and canine clinical trial sites. Instead of isolated, single-site projects, the FOA points toward coordinated efforts where clinical enrollment, sample collection, laboratory assays, and data generation can be compared and integrated across multiple funded teams. To make that feasible, NIH also set up a companion opportunity for a coordinating center under a separate mechanism (U24; RFA-CA-17-002). That coordinating center is meant to help with cross-site standardization and execution, including consistent study development practices, harmonized clinical and laboratory procedures, and centralized or coordinated data management so that results can be aggregated and interpreted more reliably across the network.
From an administrative standpoint, this is a discretionary federal funding opportunity issued by the U.S. Department of Health and Human Services through NIH. The instrument is a cooperative agreement (U01), which typically means NIH expects to have substantial scientific or programmatic involvement during the life of the award, often through collaboration on milestones, study design alignment, data expectations, and network coordination. The opportunity is associated with multiple CFDA numbers (93.393, 93.394, 93.395, 93.396, 93.399), reflecting its placement within NIH cancer-related assistance programs.
Eligibility is broad and includes many organization types that could realistically run canine clinical trials or perform the required correlative science. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations both with and without 501(c)(3) status (excluding higher education institutions where specified); for-profit organizations other than small businesses; small businesses; and other applicants as further clarified in the FOA’s eligibility text. This breadth is consistent with the network model, where clinical trial capacity might sit in veterinary schools or large practices, while specialized immunology, genomics, or pathology capabilities might sit in research institutes, universities, or industry laboratories.
In terms of funding scale and competition, the FOA anticipated about five awards, with an award ceiling of $350,000. The announcement was created on December 16, 2016, with an original closing date of March 7, 2017. Taken together, these details signal a targeted program intended to fund a small number of well-structured, network-compatible canine immunotherapy trial projects that combine rigorous clinical testing with deep mechanistic follow-up, all supported by centralized coordination through the companion U24 award.Apply for RFA CA 17 001
- The Department of Health and Human Services, National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Canine Immunotherapy Trials and Correlative Studies (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.395, 93.396, 93.399.
- This funding opportunity was created on Dec 16, 2016.
- Applicants must submit their applications by Mar 07, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $350,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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| Funding Opportunity |
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| Administrative Supplements to Promote Research Collaborations on Fusion Oncoproteins as Drivers of Childhood Cancer (Admin Supp) Apply for PA 17 138 Funding Number: PA 17 138 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $135,000 |
| Data Management and Coordinating Center (DMCC) for the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Collaborative Research Centers (CRC) (U24) Apply for RFA NS 17 022 Funding Number: RFA NS 17 022 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| NIDA Translational Avant-Garde Award for Development of Medication to Treat Substance Use Disorders (UG3/UH3) Apply for RFA DA 18 003 Funding Number: RFA DA 18 003 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $1,000,000 |
| Intensive Longitudinal Analysis of Health Behaviors: Leveraging New Technologies to Understand Health Behaviors (U01) Apply for RFA OD 17 004 Funding Number: RFA OD 17 004 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Intensive Longitudinal Analysis of Health Behaviors: Leveraging New Technologies to Understand Health Behaviors (U24) Apply for RFA OD 17 005 Funding Number: RFA OD 17 005 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Integration and Validation of Emerging Technologies to Accelerate Cancer Research (R33) Apply for RFA CA 17 023 Funding Number: RFA CA 17 023 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $325,000 |
| Limited Competition: Palliative Care Research Cooperative (PCRC) (U2C) Apply for RFA NR 17 001 Funding Number: RFA NR 17 001 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $1,000,000 |
| SBIR Phase II Bridge Awards to Accelerate the Development of Cancer Therapeutics, Imaging Technologies, Interventional Devices, Diagnostics, and Prognostics toward Commercialization (R44) Apply for RFA CA 17 024 Funding Number: RFA CA 17 024 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $1,000,000 |
| Pediatric Early Phase Clinical Trials Network (UM1) Apply for RFA CA 17 027 Funding Number: RFA CA 17 027 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $3,600,000 |
| Limited Competition: A Data Resource for Analyzing Blood and Marrow Transplants (U24) Apply for RFA CA 17 031 Funding Number: RFA CA 17 031 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $2,875,000 |
| Consortium on Translational Research in Early Detection of Liver Cancer (Clinical and Research Centers (U01) Apply for RFA CA 17 025 Funding Number: RFA CA 17 025 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $550,000 |
| Coordinating Center for the Consortium of Translational Research in Early Detection of Liver Cancer (U24) Apply for RFA CA 17 028 Funding Number: RFA CA 17 028 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $400,000 |
| Minority-Patient Derived Xenograft (PDX) Development and Trial Center (PDTC) Network (U54) Apply for RFA CA 17 032 Funding Number: RFA CA 17 032 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $800,000 |
| Research Centers for Improving Management of Symptoms Across Cancer Treatments (IMPACT) (UM1) Apply for RFA CA 17 042 Funding Number: RFA CA 17 042 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $1,120,000 |
| Coordinating Center for Improving Management of Symptoms Across Cancer Treatments (IMPACT) (U24) Apply for RFA CA 17 043 Funding Number: RFA CA 17 043 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $375,000 |
| Mechanisms of Cancer Drug Resistance and Sensitivity: Coordinating Center (U24) Apply for RFA CA 17 044 Funding Number: RFA CA 17 044 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| Accelerating Colorectal Cancer Screening and follow-up through Implementation Science (ACCSIS): Coordinating Center (U24) Apply for RFA CA 17 039 Funding Number: RFA CA 17 039 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $400,000 |
| The NCI Predoctoral to Postdoctoral Fellow Transition Award (F99/K00) Apply for RFA CA 18 001 Funding Number: RFA CA 18 001 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Innovative Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R21 - Clinical Trial Not Allowed) Apply for RFA CA 18 002 Funding Number: RFA CA 18 002 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Advanced Development and Validation of Emerging Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R33 - Clinical Trial Not Allowed) Apply for RFA CA 18 003 Funding Number: RFA CA 18 003 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
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